diff --git a/docs/source/apps.rst b/docs/source/apps.rst
index 1a2efeff48..11d60767ec 100644
--- a/docs/source/apps.rst
+++ b/docs/source/apps.rst
@@ -110,3 +110,11 @@ Clara MMARs
     :members:
 .. autoclass:: NormalizeHEStainsd
     :members:
+
+.. automodule:: monai.apps.pathology.transforms.spatial.array
+.. autoclass:: SplitOnGrid
+    :members:
+
+.. automodule:: monai.apps.pathology.transforms.spatial.dictionary
+.. autoclass:: SplitOnGridd
+    :members:
diff --git a/monai/apps/pathology/transforms/__init__.py b/monai/apps/pathology/transforms/__init__.py
index 0df016244b..1be96b8e34 100644
--- a/monai/apps/pathology/transforms/__init__.py
+++ b/monai/apps/pathology/transforms/__init__.py
@@ -9,6 +9,8 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
+from .spatial.array import SplitOnGrid
+from .spatial.dictionary import SplitOnGridd, SplitOnGridD, SplitOnGridDict
 from .stain.array import ExtractHEStains, NormalizeHEStains
 from .stain.dictionary import (
     ExtractHEStainsd,
diff --git a/monai/apps/pathology/transforms/spatial/__init__.py b/monai/apps/pathology/transforms/spatial/__init__.py
new file mode 100644
index 0000000000..07ba222ab0
--- /dev/null
+++ b/monai/apps/pathology/transforms/spatial/__init__.py
@@ -0,0 +1,13 @@
+# Copyright 2020 - 2021 MONAI Consortium
+# Licensed under the Apache License, Version 2.0 (the "License");
+# you may not use this file except in compliance with the License.
+# You may obtain a copy of the License at
+#     http://www.apache.org/licenses/LICENSE-2.0
+# Unless required by applicable law or agreed to in writing, software
+# distributed under the License is distributed on an "AS IS" BASIS,
+# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+# See the License for the specific language governing permissions and
+# limitations under the License.
+
+from .array import SplitOnGrid
+from .dictionary import SplitOnGridd, SplitOnGridD, SplitOnGridDict
diff --git a/monai/apps/pathology/transforms/spatial/array.py b/monai/apps/pathology/transforms/spatial/array.py
new file mode 100644
index 0000000000..53e0c63715
--- /dev/null
+++ b/monai/apps/pathology/transforms/spatial/array.py
@@ -0,0 +1,77 @@
+# Copyright 2020 - 2021 MONAI Consortium
+# Licensed under the Apache License, Version 2.0 (the "License");
+# you may not use this file except in compliance with the License.
+# You may obtain a copy of the License at
+#     http://www.apache.org/licenses/LICENSE-2.0
+# Unless required by applicable law or agreed to in writing, software
+# distributed under the License is distributed on an "AS IS" BASIS,
+# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+# See the License for the specific language governing permissions and
+# limitations under the License.
+
+from typing import Optional, Tuple, Union
+
+import torch
+
+from monai.transforms.transform import Transform
+
+__all__ = ["SplitOnGrid"]
+
+
+class SplitOnGrid(Transform):
+    """
+    Split the image into patches based on the provided grid shape.
+    This transform works only with torch.Tensor inputs.
+
+    Args:
+        grid_shape: a tuple or an integer define the shape of the grid upon which to extract patches.
+            If it's an integer, the value will be repeated for each dimension. Default is 2x2
+        patch_size: a tuple or an integer that defines the output patch sizes.
+            If it's an integer, the value will be repeated for each dimension.
+            The default is (0, 0), where the patch size will be infered from the grid shape.
+
+    Note: the shape of the input image is infered based on the first image used.
+    """
+
+    def __init__(
+        self,
+        grid_size: Union[int, Tuple[int, int]] = (2, 2),
+        patch_size: Optional[Union[int, Tuple[int, int]]] = None,
+    ):
+        # Grid size
+        if isinstance(grid_size, int):
+            self.grid_size = (grid_size, grid_size)
+        else:
+            self.grid_size = grid_size
+        # Patch size
+        self.patch_size = None
+        if isinstance(patch_size, int):
+            self.patch_size = (patch_size, patch_size)
+        else:
+            self.patch_size = patch_size
+
+    def __call__(self, image: torch.Tensor) -> torch.Tensor:
+        if self.grid_size == (1, 1) and self.patch_size is None:
+            return torch.stack([image])
+        patch_size, steps = self.get_params(image.shape[1:])
+        patches = (
+            image.unfold(1, patch_size[0], steps[0])
+            .unfold(2, patch_size[1], steps[1])
+            .flatten(1, 2)
+            .transpose(0, 1)
+            .contiguous()
+        )
+        return patches
+
+    def get_params(self, image_size):
+        if self.patch_size is None:
+            patch_size = tuple(image_size[i] // self.grid_size[i] for i in range(2))
+        else:
+            patch_size = self.patch_size
+
+        steps = tuple(
+            (image_size[i] - patch_size[i]) // (self.grid_size[i] - 1) if self.grid_size[i] > 1 else image_size[i]
+            for i in range(2)
+        )
+
+        return patch_size, steps
diff --git a/monai/apps/pathology/transforms/spatial/dictionary.py b/monai/apps/pathology/transforms/spatial/dictionary.py
new file mode 100644
index 0000000000..10b01a39de
--- /dev/null
+++ b/monai/apps/pathology/transforms/spatial/dictionary.py
@@ -0,0 +1,56 @@
+# Copyright 2020 - 2021 MONAI Consortium
+# Licensed under the Apache License, Version 2.0 (the "License");
+# you may not use this file except in compliance with the License.
+# You may obtain a copy of the License at
+#     http://www.apache.org/licenses/LICENSE-2.0
+# Unless required by applicable law or agreed to in writing, software
+# distributed under the License is distributed on an "AS IS" BASIS,
+# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+# See the License for the specific language governing permissions and
+# limitations under the License.
+
+from typing import Dict, Hashable, Mapping, Optional, Tuple, Union
+
+import torch
+
+from monai.config import KeysCollection
+from monai.transforms.transform import MapTransform
+
+from .array import SplitOnGrid
+
+__all__ = ["SplitOnGridd", "SplitOnGridD", "SplitOnGridDict"]
+
+
+class SplitOnGridd(MapTransform):
+    """
+    Split the image into patches based on the provided grid shape.
+    This transform works only with torch.Tensor inputs.
+
+    Args:
+        grid_shape: a tuple or an integer define the shape of the grid upon which to extract patches.
+            If it's an integer, the value will be repeated for each dimension. Default is 2x2
+        patch_size: a tuple or an integer that defines the output patch sizes.
+            If it's an integer, the value will be repeated for each dimension.
+            The default is (0, 0), where the patch size will be infered from the grid shape.
+
+    Note: the shape of the input image is infered based on the first image used.
+    """
+
+    def __init__(
+        self,
+        keys: KeysCollection,
+        grid_size: Union[int, Tuple[int, int]] = (2, 2),
+        patch_size: Optional[Union[int, Tuple[int, int]]] = None,
+        allow_missing_keys: bool = False,
+    ):
+        super().__init__(keys, allow_missing_keys)
+        self.splitter = SplitOnGrid(grid_size=grid_size, patch_size=patch_size)
+
+    def __call__(self, data: Mapping[Hashable, torch.Tensor]) -> Dict[Hashable, torch.Tensor]:
+        d = dict(data)
+        for key in self.key_iterator(d):
+            d[key] = self.splitter(d[key])
+        return d
+
+
+SplitOnGridDict = SplitOnGridD = SplitOnGridd
diff --git a/tests/test_split_on_grid.py b/tests/test_split_on_grid.py
new file mode 100644
index 0000000000..a187835e7b
--- /dev/null
+++ b/tests/test_split_on_grid.py
@@ -0,0 +1,131 @@
+# Copyright 2020 - 2021 MONAI Consortium
+# Licensed under the Apache License, Version 2.0 (the "License");
+# you may not use this file except in compliance with the License.
+# You may obtain a copy of the License at
+#     http://www.apache.org/licenses/LICENSE-2.0
+# Unless required by applicable law or agreed to in writing, software
+# distributed under the License is distributed on an "AS IS" BASIS,
+# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+# See the License for the specific language governing permissions and
+# limitations under the License.
+
+import unittest
+
+import numpy as np
+import torch
+from parameterized import parameterized
+
+from monai.apps.pathology.transforms import SplitOnGrid
+
+A11 = torch.randn(3, 2, 2)
+A12 = torch.randn(3, 2, 2)
+A21 = torch.randn(3, 2, 2)
+A22 = torch.randn(3, 2, 2)
+
+A1 = torch.cat([A11, A12], 2)
+A2 = torch.cat([A21, A22], 2)
+A = torch.cat([A1, A2], 1)
+
+TEST_CASE_0 = [
+    {"grid_size": (2, 2)},
+    A,
+    torch.stack([A11, A12, A21, A22]),
+]
+
+TEST_CASE_1 = [
+    {"grid_size": (2, 1)},
+    A,
+    torch.stack([A1, A2]),
+]
+
+TEST_CASE_2 = [
+    {"grid_size": (1, 2)},
+    A1,
+    torch.stack([A11, A12]),
+]
+
+TEST_CASE_3 = [
+    {"grid_size": (1, 2)},
+    A2,
+    torch.stack([A21, A22]),
+]
+
+TEST_CASE_4 = [
+    {"grid_size": (1, 1), "patch_size": (2, 2)},
+    A,
+    torch.stack([A11]),
+]
+
+TEST_CASE_5 = [
+    {"grid_size": 1, "patch_size": 4},
+    A,
+    torch.stack([A]),
+]
+
+TEST_CASE_6 = [
+    {"grid_size": 2, "patch_size": 2},
+    A,
+    torch.stack([A11, A12, A21, A22]),
+]
+
+TEST_CASE_7 = [
+    {"grid_size": 1},
+    A,
+    torch.stack([A]),
+]
+
+TEST_CASE_MC_0 = [
+    {"grid_size": (2, 2)},
+    [A, A],
+    [torch.stack([A11, A12, A21, A22]), torch.stack([A11, A12, A21, A22])],
+]
+
+
+TEST_CASE_MC_1 = [
+    {"grid_size": (2, 1)},
+    [A] * 5,
+    [torch.stack([A1, A2])] * 5,
+]
+
+
+TEST_CASE_MC_2 = [
+    {"grid_size": (1, 2)},
+    [A1, A2],
+    [torch.stack([A11, A12]), torch.stack([A21, A22])],
+]
+
+
+class TestSplitOnGrid(unittest.TestCase):
+    @parameterized.expand(
+        [
+            TEST_CASE_0,
+            TEST_CASE_1,
+            TEST_CASE_2,
+            TEST_CASE_3,
+            TEST_CASE_4,
+            TEST_CASE_5,
+            TEST_CASE_6,
+            TEST_CASE_7,
+        ]
+    )
+    def test_split_pathce_single_call(self, input_parameters, img, expected):
+        splitter = SplitOnGrid(**input_parameters)
+        output = splitter(img)
+        np.testing.assert_equal(output.numpy(), expected.numpy())
+
+    @parameterized.expand(
+        [
+            TEST_CASE_MC_0,
+            TEST_CASE_MC_1,
+            TEST_CASE_MC_2,
+        ]
+    )
+    def test_split_pathce_multiple_call(self, input_parameters, img_list, expected_list):
+        splitter = SplitOnGrid(**input_parameters)
+        for img, expected in zip(img_list, expected_list):
+            output = splitter(img)
+            np.testing.assert_equal(output.numpy(), expected.numpy())
+
+
+if __name__ == "__main__":
+    unittest.main()
diff --git a/tests/test_split_on_grid_dict.py b/tests/test_split_on_grid_dict.py
new file mode 100644
index 0000000000..96ec095423
--- /dev/null
+++ b/tests/test_split_on_grid_dict.py
@@ -0,0 +1,131 @@
+# Copyright 2020 - 2021 MONAI Consortium
+# Licensed under the Apache License, Version 2.0 (the "License");
+# you may not use this file except in compliance with the License.
+# You may obtain a copy of the License at
+#     http://www.apache.org/licenses/LICENSE-2.0
+# Unless required by applicable law or agreed to in writing, software
+# distributed under the License is distributed on an "AS IS" BASIS,
+# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+# See the License for the specific language governing permissions and
+# limitations under the License.
+
+import unittest
+
+import numpy as np
+import torch
+from parameterized import parameterized
+
+from monai.apps.pathology.transforms import SplitOnGridDict
+
+A11 = torch.randn(3, 2, 2)
+A12 = torch.randn(3, 2, 2)
+A21 = torch.randn(3, 2, 2)
+A22 = torch.randn(3, 2, 2)
+
+A1 = torch.cat([A11, A12], 2)
+A2 = torch.cat([A21, A22], 2)
+A = torch.cat([A1, A2], 1)
+
+TEST_CASE_0 = [
+    {"keys": "image", "grid_size": (2, 2)},
+    {"image": A},
+    torch.stack([A11, A12, A21, A22]),
+]
+
+TEST_CASE_1 = [
+    {"keys": "image", "grid_size": (2, 1)},
+    {"image": A},
+    torch.stack([A1, A2]),
+]
+
+TEST_CASE_2 = [
+    {"keys": "image", "grid_size": (1, 2)},
+    {"image": A1},
+    torch.stack([A11, A12]),
+]
+
+TEST_CASE_3 = [
+    {"keys": "image", "grid_size": (1, 2)},
+    {"image": A2},
+    torch.stack([A21, A22]),
+]
+
+TEST_CASE_4 = [
+    {"keys": "image", "grid_size": (1, 1), "patch_size": (2, 2)},
+    {"image": A},
+    torch.stack([A11]),
+]
+
+TEST_CASE_5 = [
+    {"keys": "image", "grid_size": 1, "patch_size": 4},
+    {"image": A},
+    torch.stack([A]),
+]
+
+TEST_CASE_6 = [
+    {"keys": "image", "grid_size": 2, "patch_size": 2},
+    {"image": A},
+    torch.stack([A11, A12, A21, A22]),
+]
+
+TEST_CASE_7 = [
+    {"keys": "image", "grid_size": 1},
+    {"image": A},
+    torch.stack([A]),
+]
+
+TEST_CASE_MC_0 = [
+    {"keys": "image", "grid_size": (2, 2)},
+    [{"image": A}, {"image": A}],
+    [torch.stack([A11, A12, A21, A22]), torch.stack([A11, A12, A21, A22])],
+]
+
+
+TEST_CASE_MC_1 = [
+    {"keys": "image", "grid_size": (2, 1)},
+    [{"image": A}] * 5,
+    [torch.stack([A1, A2])] * 5,
+]
+
+
+TEST_CASE_MC_2 = [
+    {"keys": "image", "grid_size": (1, 2)},
+    [{"image": A1}, {"image": A2}],
+    [torch.stack([A11, A12]), torch.stack([A21, A22])],
+]
+
+
+class TestSplitOnGridDict(unittest.TestCase):
+    @parameterized.expand(
+        [
+            TEST_CASE_0,
+            TEST_CASE_1,
+            TEST_CASE_2,
+            TEST_CASE_3,
+            TEST_CASE_4,
+            TEST_CASE_5,
+            TEST_CASE_6,
+            TEST_CASE_7,
+        ]
+    )
+    def test_split_pathce_single_call(self, input_parameters, img_dict, expected):
+        splitter = SplitOnGridDict(**input_parameters)
+        output = splitter(img_dict)[input_parameters["keys"]]
+        np.testing.assert_equal(output.numpy(), expected.numpy())
+
+    @parameterized.expand(
+        [
+            TEST_CASE_MC_0,
+            TEST_CASE_MC_1,
+            TEST_CASE_MC_2,
+        ]
+    )
+    def test_split_pathce_multiple_call(self, input_parameters, img_list, expected_list):
+        splitter = SplitOnGridDict(**input_parameters)
+        for img_dict, expected in zip(img_list, expected_list):
+            output = splitter(img_dict)[input_parameters["keys"]]
+            np.testing.assert_equal(output.numpy(), expected.numpy())
+
+
+if __name__ == "__main__":
+    unittest.main()